Diagnostic clues in patients with clinical malabsorption and pathological small intestinal villous atrophy: Immune-mediated type and beyond

Figure 1 Representative histopathological features of small intestinal villous atrophy disorders. A: Duodenal biopsy from a patient with autoimmune enteropathy showing complete villous atrophy, loss of goblet cells and Paneth cells, and apoptotic bodies (arrow) [hematoxylin & eosin (H&E), × 100]; B: Duodenal biopsy from a patient with common variable immunodeficiency showing blunted villi and absence of plasma cells (H&E, × 100); C: Ileal biopsy from a patient with monomorphic epitheliotropic intestinal T-cell lymphoma showing dense infiltration of small T lymphocytes (H&E, × 40); D: Duodenal biopsy from a patient with eosinophilic gastroenteritis showing marked eosinophilic infiltration (H&E, × 100).