Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy

Figure 1 Patient disposition chart. PSM: Propensity score matching; MgIG: Magnesium isoglycyrrhizinate.

Figure 2 The proportion of patients with postoperative liver injury. A: The proportion of patients with postoperative liver injury who received perioperative magnesium isoglycyrrhizinate vs those who received postoperative magnesium isoglycyrrhizinate only; B-D: Changes in serum alanine aminotransferase (ALT); E-G: Changes in serum aspartate aminotransferase (AST) levels. Postoperative liver injury is defined as ≥ 3 × upper limit of normal of the serum ALT or AST levels. Group number: A2-2 means prophylaxis group in which patients were treated with perioperative magnesium isoglycyrrhizinate plus postoperative other liver protectants; B2-2 means non-prophylaxis group in which patients were treated with postoperative magnesium isoglycyrrhizinate plus postoperative other liver protectants. ^aP < 0.05. ^bP < 0.01. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; POD: Postoperative day; NS: Not significant.

Figure 3 Analysis of prevalence of hepatic injury post hepatectomy. A: Using generalized estimating equation; B-D: Changes in serum alanine aminotransferase and aspartate aminotransferase levels in the prophylaxis group (A0) vs the non-prophylaxis group (B0). ^aP < 0.05. ^cP < 0.001. POD: Postoperative day; CI: Confidence interval; OR: Odds ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Figure 4 Changes in serum alanine aminotransferase and aspartate aminotransferase levels in the group (B2-2) upon treatment with magnesium isoglycyrrhizinate plus other liver protectants vs the control group (B2-3) upon treatment with other liver protectants. A-H: The levels, changes from postoperative day 1, proportions of patients with ≥ 50% reduction in the serum levels of aminotransferase and the proportions of patients who had normalized serum alanine aminotransferase (A-D) and aspartate aminotransferase levels (E-H) post hepatectomy. ^aP < 0.05. ^cP < 0.001. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; POD: Postoperative day; NS: Not significant.