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Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy
Zhi-Qin Xie, Jin-Xing Wei, Jin-Yi Zhong, Xuan Luo, Hong-Kai Zhuang, Xiao-Wu Ma, Qing-Bin Wang, Wen-Liang Tan, Bing-Kun Wang, Ya-Jin Chen, Chuan-Jiang Li, Chang-Zhen Shang
Zhi-Qin Xie, Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, Hunan Province, China
Jin-Xing Wei, Jin-Yi Zhong, Xuan Luo, Hong-Kai Zhuang, Xiao-Wu Ma, Qing-Bin Wang, Bing-Kun Wang, Ya-Jin Chen, Chang-Zhen Shang, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Wen-Liang Tan, Department of Hepatobiliary and Pancreatic Surgery, Medical Center of Digestive Diseases, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China
Chuan-Jiang Li, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Co-first authors: Zhi-Qin Xie and Jin-Xing Wei.
Co-corresponding authors: Chuan-Jiang Li and Chang-Zhen Shang.
Author contributions: Xie ZQ, Wei JX, Zhong JY contributed to conceptualization, data curation, formal analysis, methodology, resources and writing-original draft; Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL and Wang BW contributed to data curation; Chen YJ and Shang CZ contributed to conceptualization, resources, funding acquisition and writing, review and editing; Li CJ contributed to conceptualization, resources, and writing, review and editing; all authors approved the final version, and agree to be accountable for all aspects of the work.
Supported by the National Natural Science Foundation of China, No. 82573407; Basic and Applied Basic Research Foundation of Guangdong Province, No. 2023A1515220211; and the Furong Plan Health High Level Talent Project of Hunan Province, No. 20250924-1015.
Institutional review board statement: The study protocol was approved by the Medical Ethics Committee of Sun Yat-sen Memorial Hospital, Sun Yat-sen University (No. SYSKY-2023-1199-01) and Medical Ethics Committee of NanFang Hospital of Southern Medical University (No. NFEC-2024-051).
Informed consent statement: The study protocol was approved by the local ethics committee or institutional review board of each participating center. Patient consent was not required given the retrospective nature of the study. Protocols, data storage, and data use were compliant with international data privacy laws.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data are not publicly available due to restrictions for their containing information that could compromise the privacy of research patients.
Corresponding author: Chang-Zhen Shang, MD, Professor, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 33 Yingfeng Road, Haizhu District, Guangzhou 510120, Guangdong Province, China.
shchzh2@mail.sysu.edu.cn
Received: November 14, 2025
Revised: January 13, 2026
Accepted: February 26, 2026
Published online: May 21, 2026
Processing time: 186 Days and 20 Hours
