Pescadillo ribosomal biogenesis factor 1 as a therapeutic target in tumor immunotherapy

Figure 1 Correlation analysis of pescadillo ribosomal biogenesis factor 1 expression with immune markers in gastric cancer from The Cancer Genome Atlas database. A: Scatter plot showing the correlation between pescadillo ribosomal biogenesis factor 1 expression (log2-transformed) and CD8+ T cell infiltration levels in gastric cancer tissues; B: Scatter plot demonstrating the correlation between programmed death-ligand 1 expression and pescadillo ribosomal biogenesis factor 1 expression in gastric cancer samples. PES1: Pescadillo ribosomal biogenesis factor 1.

Figure 2 Proposed molecular mechanisms underlying pescadillo ribosomal biogenesis factor 1-mediated regulation of programmed death-ligand 1 expression and tumor immune evasion. Created with Figdraw.com. PD-L1: Programmed death-ligand 1; PES1: Pescadillo ribosomal biogenesis factor 1; PD-1: Programmed cell death protein 1; mTORC: Mechanistic target of rapamycin complex; AKT: Protein kinase B; PDK1: 3-phosphoinositide dependent protein kinase-1; PIP2: Phosphatidylinositol 4,5-bisphosphate; PIP3: Phosphatidylinositol (3,4,5)-trisphosphate; PTEN: Phosphatase and tensin homolog; BRD4: Bromodomain-containing protein 4; c-Myc: Myelocytomatosis oncogene.