Important role of tumor deposits and negative lymph nodes in prognosis of N1c colorectal cancer patients

Figure 1 Three groups divided according to the number of tumor deposits had different prognosis (tumor deposits = 1, tumor deposits = 2 and tumor deposits > 2). A: Tumor deposits (TDs) predicting disease-free survival (P = 0.002); B: TD predicting overall survival (P = 0.490); C: TD predicting cancer-specific survival (P = 0.360). TD: Tumor deposits.

Figure 2 Prognosis in groups divided according to > 12 or < 12 negative lymph nodes. A: Negative lymph node (NLN) status predicting disease-free survival (P = 0.058); B: NLN status predicting overall survival (P = 0.190); C: NLN status predicting cancer-specific survival (P = 0.110). NLN: Negative lymph node.

Figure 3 Prognosis in groups divided according to the cutoff value of combination of tumor deposits and negative lymph node. A: Combination of tumor deposits and negative lymph node (NLNTD) predicting disease-free survival (P = 0.005); B: NLNTD predicting overall survival (P = 0.052); C: NLNTD predicting cancer-specific survival (P = 0.019). NLNTD: Combination of tumor deposits and negative lymph node.

Figure 4 Prognosis in groups divided according to the cutoff value of combination of tumor deposits and negative lymph node in subgroups without perineural invasion or lymphovascular invasion. A: Combination of tumor deposits and negative lymph node (NLNTD) predicting disease-free survival (DFS) in subgroup without perineural invasion (PNI) (P = 0.012); B: NLNTD predicting overall survival (OS) in subgroup without PNI (P = 0.008); C: NLNTD predicting cancer-specific survival (CSS) in subgroup without PNI (P = 0.008); D: NLNTD predicting DFS in subgroup without lymphovascular invasion (LVI) (P = 0.002); E: NLNTD predicting OS in subgroup without LVI (P = 0.074); F: NLNTD predicting CSS in subgroup without LVI (P = 0.074); G: NLNTD predicting DFS in subgroup without LVI and PNI (P = 0.053); H: NLNTD predicting OS in subgroup without LVI and PNI (P = 0.049); I: NLNTD predicting CSS in subgroup without LVI and PNI (P = 0.049). NLNTD: Combination of tumor deposits and negative lymph node; PNI: Perineural invasion; LVI: Lymphovascular invasion.