Cholangiocarcinoma: The era of liquid biopsy

doi:10.3748/wjg.v31.i11.104170

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Mar 21, 2025 (publication date) through Apr 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 104170
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.104170

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Figure 1 The spectrum of liquid biopsy in cholangiocarcinoma: Types, biomarkers and applications. PCR: Polymerase chain reaction; NGS: Next-generation sequencing; CTCs: Circulating tumour cells; cfDNA: Cell-free DNA; ctDNA: Circulating tumour DNA; EVs: Extracellular vesicles; IDH: Isocitrate dehydrogenase; FGFR2: Fibroblast growth factor receptor 2.

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Figure 2 Key findings of major studies on liquid biopsy in cholangiocarcinoma. CCA: Cholangiocarcinoma; CDO1: Cysteine dioxygenase type 1; CNRIP1: Cannabinoid receptor interacting protein 1; SEPT9: Septin 9; VIM: Vimentin; AUC: Area under the curve; Sens: Sensitivity; Sp: Specificity; PSC: Primary sclerosing cholangitis; NGS: Next generation sequencing; CTC: Circulating tumour cells; cfDNA: Cell-free DNA; CI: Confidence interval; HR: Hazard ratio; ctDNA: Circulating tumour DNA; DFS: Disease-free survival.

Citation: Kotsifa E, Saffioti F, Mavroeidis VK. Cholangiocarcinoma: The era of liquid biopsy. World J Gastroenterol 2025; 31(11): 104170
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/104170.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.104170