PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

Figure 1 Comparison of various quantitative phenotypes (hepatic histological features and mRNA expression) in patients with nonalcoholic fatty liver disease at the PPARGC1A rs8192678 polymorphism. A-E: Prevalence of moderate-severe steatosis (S2-3), activity 2-4 (A ≥ 2), significant fibrosis (F2-4), advanced fibrosis (F3-4), and nonalcoholic steatohepatitis according to the PPARGC1A rs8192678 polymorphism in 59 patients with nonalcoholic fatty liver disease. The reference genotype for the PPARGC1A rs8192678 polymorphism was GG, and a mode of dominant inheritance was used; F: The intrahepatic mRNA expression of PPARGC1A between the GG group (n = 5) and the GA or AA group (n = 5) at PPARGC1A rs8192678. NASH: Nonalcoholic steatohepatitis.