Zhang RN, Shen F, Pan Q, Cao HX, Chen GY, Fan JG. PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease . World J Gastroenterol 2021; 27(25): 3863-3876 [PMID: 34321850 DOI: 10.3748/wjg.v27.i25.3863]
Corresponding Author of This Article
Jian-Gao Fan, MD, PhD, Director, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Zhang RN, Shen F, Pan Q, Cao HX, Chen GY, Fan JG. PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease . World J Gastroenterol 2021; 27(25): 3863-3876 [PMID: 34321850 DOI: 10.3748/wjg.v27.i25.3863]
World J Gastroenterol. Jul 7, 2021; 27(25): 3863-3876 Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3863
PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease
Rui-Nan Zhang, Feng Shen, Qin Pan, Hai-Xia Cao, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Guang-Yu Chen, Clinical Epidemiology Research Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Jian-Gao Fan, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China
Author contributions: Zhang RN and Shen F contributed equally to this work; Zhang RN, Pan Q, Shen F, Chen GY, and Cao HX enrolled the cohorts and collected blood samples; Zhang RN, Pan Q, and Shen F performed genotyping; Zhang RN, Pan Q interpreted the data and were involved in the manuscript preparation; Fan JG designed and supervised the study; Zhang RN and Fan JG wrote the manuscript.
Supported byNational Key R&D Program of China, No. 2017YFC0908903; National Natural Science Foundation of China, No. 81700503, No. 81873565, and No. 81470840; WBE Liver Fibrosis Foundation, No. CFHPC2020061; and Hospital Funded Clinical Research, Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 17CSK04.
Institutional review board statement: This study was approved by the institutional review board of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Corresponding author: Jian-Gao Fan, MD, PhD, Director, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Received: February 8, 2021 Peer-review started: February 8, 2021 First decision: March 28, 2021 Revised: April 8, 2021 Accepted: April 20, 2021 Article in press: April 20, 2021 Published online: July 7, 2021 Processing time: 147 Days and 13.3 Hours
Core Tip
Core Tip: The PPARGC1A rs8192678 A allele was found to be a risk factor for liver biopsy-proven nonalcoholic fatty liver disease (NAFLD) after adjusting for age, sex, and patatin-like phospholipase domain-containing protein 3 rs738409 polymorphism. The multivariate logistic regression analysis showed that the PPARGC1A rs8192678 risk A allele was also independently associated with the severity of hepatic histological features (S2-3 and A ≥ 2) and nonalcoholic steatohepatitis (NASH), and might also be associated with nonobese NASH, indicating that the PPARGC1A rs8192678 risk A allele was associated with NAFLD in the Chinese Han adult population. Also, the intrahepatic expression of PPARGC1A mRNA was significantly lower in the patients who carried the risk A allele, implying that it might be a genetic contribution to the pathogenesis of NAFLD.
