High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data

Figure 1 Study selection for the systematic review.

Figure 2 Major liver histological features observed in 6 studies (n = 116 autopsies from deceased coronavirus disease 2019 patients). Steatosis was the most frequent finding (55.1%). Studies also reported congestion of hepatic sinuses (34.6%), vascular thrombosis (29.4%), fibrosis (20.5%), Kupffer cell hyperplasia (13.5%), portal inflammation (13.2%), and lobular inflammation (11.6%), Other findings observed were venous outflow obstruction, phlebosclerosis of the portal vein, herniated portal vein, periportal abnormal vessels, hemophagocytosis, and necrosis. 

Figure 3 Forest plots of major liver histological features from deceased coronavirus disease 2019 patients. A-D: The figure includes forest plots of hepatic steatosis (A), congestion of hepatic sinuses (B), vascular thrombosis (C), and fibrosis (D). Heterogeneity was assessed using I² and Q statistics. CI: Confidence interval.

Figure 4 Forest plots of inflammatory liver histological features from deceased coronavirus disease 2019 patients. A-C: The figure includes forest plots of Kupffer cell hyperplasia (A), portal inflammation (B), and lobular inflammation (C). Heterogeneity was assessed using I² and Q statistics. CI: Confidence interval.