Effects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury

Figure 1 Histological images and pathologic and edema scores of pancreatic, lung, and kidney tissues in the three study groups. A: Pathological images of the pancreatic, lung, and kidney tissues (hematoxylin-eosin staining, magnification: pancreas and kidney × 200; lung × 100); B: Histological scores of the three types of tissues; C: Edema scores of the three types of tissues. The results are represented as the mean ± SD. ^aP < 0.05 (n = 12). SOG: Sham operation group; MG: Model group; TG: Treatment group.

Figure 2 Levels of lung injury factors. A: Levels of superoxide dismutase in three groups; B: Levels of malondialdehyde in three groups. The results are represented as the mean ± SD. ^aP < 0.05, NS: P > 0.05 (n = 12). SOG: Sham operation group; MG: Model group; TG: Treatment group; SOD: Superoxide dismutase; MDA: Malondialdehyde.

Figure 3 Western blot analysis of expression of aquaporins and acute renal injury biomarkers. A: Grayscale images and relative expression of aquaporins in three groups; B: Grayscale images and relative expression of acute renal injury biomarkers in three groups. The results are represented as the mean ± SD. ^aP < 0.05; NS: P > 0.05 (n = 12). SOG: Sham operation group; MG: Model group; TG: Treatment group; MDA: Malondialdehyde; KIM-1: Kidney injury molecule-1; α-SMA: α-smooth muscle actin.

Figure 4 Aquaporins and kidney injury molecule-1 mRNA expression in three groups. The results are represented as the mean ± SD. ^aP < 0.05; NS: P > 0.05 (n = 12). MG: Model group; TG: Treatment group; KIM-1: Kidney injury molecule-1; AQP1: Aquaporin 1.