Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors

Figure 1 First and second line therapies for advanced hepatocellular carcinoma. RECIST: Response Evaluation Criteria for Solid Tumors; ECOG: Eastern Cooperative Oncology Group; SOR: Sorafenib.

Figure 2 Radiological tumor response between sorafenib and lenvatinib according to RECIST 1. 1 criteria, reported in the REFLECT trial. RECIST: Response Evaluation Criteria for Solid Tumors; ORR: Objective response rate.

Figure 3 Clinical “stopping rules” of first and second line tyrosine kinase inhibitors. RECIST: Response Evaluation Criteria for Solid Tumors; ECOG: Eastern Cooperative Oncology Group; RECIST: Response Evaluation Criteria for Solid Tumors criteria.

Figure 4 Flow chart for clinical-decision making processes of first and second line systemic treatment for advanced hepatocellular carcinoma. BCLC: Barcelona Clinic Liver Cancer; ECOG: Eastern Cooperative Oncology Group.