Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma

doi:10.3748/wjg.v21.i42.12022

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Nov 14, 2015 (publication date) through Oct 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2015; 21(42): 12022-12041
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12022

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Figure 1 Schematic representation of various treatment strategies for hepatocellular carcinoma at different stages according to the Barcelona Clinic Liver Cancer algorithm. RFA: Radiofrequency ablation, PEI: Percutaneous ethanol injection; TACE: Trans catheter arterial chemoembolization.

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Figure 2 Different methods of targeted delivery of nanoparticles by passive or active mechanism. EPR: Enhanced permeation and retention.

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Figure 3 Schematic representation of the biotinylated cyclic Arg-Gly-Asp nanoparticles loaded with doxorubicin. PEG: Polyethylene glycol; RGD: Arg-Gly-Asp.

Citation: Varshosaz J, Farzan M. Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12022-12041
URL: https://www.wjgnet.com/1007-9327/full/v21/i42/12022.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i42.12022