Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn’s disease

Figure 1 Flow chart of the literature search and study selection. Seven case-control studies were included in this meta-analysis.

Figure 2 Forest plots of the relationships between interleukin-18 genetic polymorphisms and the risk of developing Crohn’s disease, using the allele and dominant models.

Figure 3 Subgroup analyses of the relationships between interleukin-18 genetic polymorphisms and the risk of developing Crohn’s disease, using the allele and dominant models.

Figure 4 Sensitivity analysis of the summary odds ratio coefficients for the relationships between interleukin-18 genetic polymorphisms and the risk of developing Crohn’s disease, using the allele and dominant models.

Figure 5 Funnel plot of publication biases of the relationships between interleukin-18 genetic polymorphisms and the risk of Crohn’s disease under the allele and dominant models. W: Wild-type allele; M: Mutant allele; WW: Wild-type homozygote; WM: Heterozygote; MM: Mutant homozygote; OR: Odds ratio.