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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8711-8722
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8711
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8711
Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn’s disease
Su-Jun Gao, Li Zhang, Wei Lu, Lu Wang, Lei Chen, Zhen Zhu, Hai-Hang Zhu, Department of Gastroenterology, Subei People’s Hospital, Yangzhou 225001, Zhejiang Province, China
Author contributions: Gao SJ, Zhang L and Lu W designed the study, analyzed data and wrote the manuscript as co-first authors; Zhang L contributed to the discussions and wrote the manuscript; Wang L, Chen L and Zhu Z edited the manuscript; Lu W and Zhu HH designed the study, contributed to the discussions and edited the manuscript as a corresponding author; Gao SJ, Zhang L and Lu W contributed equally to this article as first author(s).
Conflict-of-interest statement: The authors have declared that they have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hai-Hang Zhu, Department of Gastroenterology, Subei People’s Hospital, No. 98 Nantong Street, Yangzhou 225001, Zhejiang Province, China. doczhuhaihang@163.com
Telephone: +86-514-87373385 Fax: +86-514-87373385
Received: August 22, 2014
Peer-review started: August 23, 2014
First decision: October 29, 2014
Revised: December 5, 2014
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: July 28, 2015
Processing time: 341 Days and 18.4 Hours
Peer-review started: August 23, 2014
First decision: October 29, 2014
Revised: December 5, 2014
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: July 28, 2015
Processing time: 341 Days and 18.4 Hours
Core Tip
Core tip: This meta-analysis was performed to evaluate the relationships between genetic polymorphisms in the Interleukin-18 gene and the risk of developing Crohn’s disease.