Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies

Figure 1 Summary of evidence search and selection.

Figure 2 Forest plot: results from individual studies and meta-analyses. The RR and 95%CI for each study are displayed on a logarithmic scale. Pooled estimates are from a random-effects model.

Figure 3 Funnel plot of observed relative risk against standard error (as a surrogate of study size) for all studies analyzed. RCT: Randomized controlled trials.

Figure 4 L’Abbé plot of the incidence of colorectal cancer in the experimental (statin) group, against the incidence in the control group, across the analyzed randomized controlled trials (n = 8).

Figure 5 ‘‘Leave-one-out” sensitivity analysis for the three meta-analyses: pooled estimates are from random-effects models with one study omitted at a time. A: Randomized controlled trials, B: Cohort studies, C: Case-control studies.