Preclinical evaluation of herpes simplex virus armed with granulocyte-macrophage colony-stimulating factor in pancreatic carcinoma

Figure 1 Inhibition of herpes simplex virus encoding granulocyte-macrophage colony-stimulating factor on the proliferation of PANC-2 pancreatic carcinoma xenografts in mice. A: Control group; B: High dosage; C: Middle dosage; D: Low dosage. Fifteen days later, after decapitation of the animals by cervical dislocation, each tumor was isolated.

Figure 2 Effect of OrienX010 on the tumor volume (A) and tumor weight (B) of PANC-2 pancreatic carcinoma xenografts in mice. pfu: Plaque forming units.

Figure 3 Changes in relative mouse body weights. pfu: Plaque forming units.

Figure 4 Quantification of expressed granulocyte-macrophage colony-stimulating factor. pfu: Plaque forming units; GM-CSF: Granulocyte-macrophage colony-stimulating factor.