Biochemical characteristics of neonatal cholestasis induced by citrin deficiency

Figure 1 Comparison of the age when conjugated jaundice was first noticed (A), biochemistry indices (B-E), and ratios of some biochemical indices (F-H) in patients with neonatal intrahepatic cholestasis caused by citrin deficiency, idiopathic neonatal cholestasis and biliary atresia. ^aP < 0.05 between BA and INC; ^cP < 0.05 between BA and NICCD; ^eP < 0.05 between INC and NICCD. Normal range: T-Bil (2-20 μmol/L), D-Bil (0-6 μmol/L), total bile acids (< 40 μmol/L), and TCH (3.12-5.20 mmol/L). NICCD: Neonatal intrahepatic cholestasis caused by citrin deficiency; BA: Biliary atresia; INC: Idiopathic neonatal cholestasis; TBA: Total bile acid; T-Bil: Total bilirubin; D-Bil: Direct bilirubin; TCH: Total cholesterol.