Intrahepatic expression of genes related to metabotropic receptors in chronic hepatitis

Figure 1 Agglomerative hierarchical clustering methods of genes expression. The dendrogram assigned to the numerical value on the horizontal axis describes the patients’ correlation; the dendrogram assigned to individual genes on the vertical axis describes the genes’ correlation. Figures on the x-axis denote patient order. VCAM1: Vascular cell adhesion molecule 1; TSHR: Thyroid stimulating hormone receptor; CCL4: Chemokine (C-C motif) ligand 4; CALCR: Calcitonin receptor; PDPK1: 3-phosphoinositide-dependent protein kinase-1; PIK3CG: Phosphoinositide 3-kinase; IL1β: Interleukin 1β; AKT1: Protein kinase A; GNAS: α subunit of G-coupled protein; ARRB2: Arrestin β; IL1R1: Interleukin 1 receptor, type I; CSF3: Colony stimulating factor-3; ELK4: ETS-domain protein; AGT: Angiotensinogen; JUN-B: Transcription factor jun-B; IL1R2: Interleukin 1 receptor, type II; EDG1: Sphingosine-1-phosphate receptor 1; DUSP14: Dual-specificity protein phosphatases 14; EGR1: Early growth response protein 1; EDG2: Lysophosphatidic acid receptor.

Figure 2 Agglomerative hierarchical clustering methods of clinical features expression. The dendrogram assigned to a numerical value on the horizontal axis describes the patients’ correlation; the dendrogram assigned to individual clinical features on the vertical axis describes the clinical features’ correlation. Figures on the x-axis denote patient order.

Figure 3 Arithmetic mean of gene activity. There was a statistically significant difference in the Wilcoxon signed-rank test between the genes with the highest expression, GNAS, PDPK1, AGT, and ARRB2, and moderate expression, PIK3CG, AKT1, IL1β, VCAM1, CALCR, and JUN-B, and between the genes with moderate expression and the remaining genes with low expression.