Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma

Figure 1 Cyclooxygenase-2 expression. A: Strong diffuse brown cytoplasmic cyclooxygenase-2 (COX-2) expression in colorectal adenocarcinoma cells, in contrast to negative expression in normal colonic cells; B: Negative COX-2 expression in poorly differentiated colorectal adenocarcinoma. Note the positive expression of stromal inflammatory cells.

Figure 2 Diffuse positive cytoplasmic cyclooxygenase-2 expression of mucoid carcinoma.

Figure 3 Impact of cyclooxygenase-2 expression on survival in univariate (Kaplan-Meier) analysis. A: Disease-free survival (P = 0.026); B: Disease-specific survival (P = 0.318).