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©2010 Baishideng.
World J Gastroenterol. Aug 21, 2010; 16(31): 3897-3904
Published online Aug 21, 2010. doi: 10.3748/wjg.v16.i31.3897
Published online Aug 21, 2010. doi: 10.3748/wjg.v16.i31.3897
Figure 1 Immunohistochemical expression of protein S100A4.
A: Protein S100A4 expression in normal colorectal epithelium. In all normal colonic epithelium, protein S100A4 immunoreactivity was clearly absent at both cytoplasm and nucleus; B: Negative expression of protein S100A4 in colorectal cancer (CRC); C: Positive expression of protein S100A4 in CRC. Cytoplasm of cancer cells was diffusely stained brown (all at × 200 magnification).
Figure 2 Immunohistochemical expression of E-cadherin.
A: E-cadherin expression in normal colorectal epithelium. Normal epithelial cells strongly and homogeneously expressed E-cadherin at intercellular boundaries; B: Preserved expression of E-cadherin in colorectal cancer (CRC); C: Reduced expression of E-cadherin in CRC. Staining of cancer cell at intercellular border was weak and heterogeneous (all at × 200 magnification).
Figure 3 Immunohistochemical expression of p53.
A: p53 expression in normal colorectal epithelium. In all normal colonic epithelium, p53 immunoreactivity was clearly absent at nucleus; B: Negative expression of p53 in colorectal cancer (CRC); C: Positive expression of p53 in CRC. More than 10% of cancer cells were stained strongly at their nuclei (all at × 200 magnification).
Figure 4 Kaplan-Meier survival curves demonstrating statistically significant differences according to the expression of protein S100A4 (log-rank test, P = 0.
044). Censored observations are shown as tick marks.
- Citation: Kwak JM, Lee HJ, Kim SH, Kim HK, Mok YJ, Park YT, Choi JS, Moon HY. Expression of protein S100A4 is a predictor of recurrence in colorectal cancer. World J Gastroenterol 2010; 16(31): 3897-3904
- URL: https://www.wjgnet.com/1007-9327/full/v16/i31/3897.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i31.3897