Stevens-Johnson syndrome complicating adalimumab therapy in Crohn’s disease

Figure 1 Mucosal lesions. A: Lip involvement with target-lesion on left upper lip progressing to a bullae (black arrow); B: Tongue desquamation demonstrated as white plaques (white arrows).

Figure 2 Chest X-Ray. Patchy bilateral alveolar infiltrates consistent with bronchialpneumonia.

Figure 3 Histology of skin biopsies. The epidermis shows mild irregular acanthosis with a small amount of overlying compact keratin (thin arrow). There is superficial dermal oedema associated with vacuolar change of the basal layer of the epidermis (thick arrow). Within the dermis is a mixed inflammatory cell infiltrate. The findings are consistent with erythema multiforme. A: 25 × magnification; B: Insert at 100 × magnification.