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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Feb 7, 2008; 14(5): 731-736
Published online Feb 7, 2008. doi: 10.3748/wjg.14.731
Published online Feb 7, 2008. doi: 10.3748/wjg.14.731
Figure 1 Colitis-induced changes in colonic mucosal MPO activity (A), plasma level of CRH (B), and visceral nociceptive AWR (C).
In panel A and B, the upper and lower whiskers indicate the maximum and minimum values, respectively. Box lines represent the 25th (bottom), 50th (middle) and 75th (top) percentile value; (C) The area under the curve (AUC) calculated from the stimulus-response plot is illustrated as a bar graph on the right side. aP < 0.05, bP < 0.01 vs control by MWU test after KW test (P < 0.01).
Figure 2 Effect of CRH receptor antagonist astressin (A) and CRH (B) on the colorectal distension-induced AWR behavior.
In each panel, the bar graphs on the right side represent the AUC of the stimulus-response plot. Astressin (AST, 30 &mgr;g/kg) and CRH (1, 3 and 10 &mgr;g/kg) were administered intraperitoneally. The same amount of saline was given as a vehicle (Veh). aP < 0.05 vs the paired group in (A) or the Veh group in (B) by MWU test after KW test (P < 0.05).
- Citation: La JH, Sung TS, Kim HJ, Kim TW, Kang TM, Yang IS. Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats. World J Gastroenterol 2008; 14(5): 731-736
- URL: https://www.wjgnet.com/1007-9327/full/v14/i5/731.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.731