Characteristics of liver on magnetic resonance diffusion-weighted imaging: Dynamic and image pathological investigation in rabbit liver VX-2 tumor model

Figure 1 A: The area of VX-2 tumor center; B: The area of VX-2 tumor periphery; C: The area of VX-2 tumor outer layer; D: The normal liver parenchyma area around tumor when the values of ADC and signals were measured on DWI and samples were investigated pathologically.

Figure 2 The average diameter of VX-2 tumors on the 7th, the 14th and the 21th d after implantation detected by DWI, T1- and T2 weighted imaging.

Figure 3 Image manifestations of hepatic VX-2 tumor on DWI, ADC map, T1WI or T2WI. A: A1, a low signal and obscure margin of VX-2 tumor on T1WI and A2, a slightly high signal on T2WI on the 7th day after implantation; B: a high signal and distinct margin of VX-2 tumor on DWI when b value was 100 (B1) or 300 (B2) s/mm² and low SNR when b value was 300 (B2) s/mm² on the 7th day after implantation; C: C1, a low signal of VX-2 tumor on T1WI and C2, a slightly high signal of it on T2WI and a lamellar high signal in the tumor center on T2WI on the 14th day after implantation; D: A high signal and distinct margin of VX-2 tumor on DWI when b value was 100 s/mm² (D1) and low signal of VX-2 tumor and a lamellar high signal in its center on the map of ADC on the 14th d after implantation (D2); E: A high and uneven signal of VX-2 tumor on DWI when b value was 100 s/mm² (E1) and low signal of VX-2 tumor while a high signal in the center tumor on the map of ADC on the 21th d after implantation (E2).

Figure 4 Cavitas was observed in the tumor center of some samples on the 21th d after implantation.

Figure 5 Cell nest of VX-2 tumor and wide zone of necrosis in the tumor were observed under microscope (up x 100, down x 400).