Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues

Figure 1 Expression of PTEN in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues (Envision, x 200). A: Expression of PTEN in the nucleus, cytoplasm and membrane of normal liver tissues; B: Expression of PTEN in the cytoplasm and membrane of hepatitis tissue; C: Expression of PTEN in the nucleus, cytoplasm and membrane of cirrhotic liver tissues; D: Expression of PTEN weakly in the cytoplasm of HCC, strongly in the cytoplasm and membrane of paracancerous tissues; E: Strong expression of PTEN in the cytoplasm of HCC with Edmondson gradeI; F: Expression of PTEN in the cytoplasm and membrane of HCC with grade II; G: Weak expression of PTEN in the cytoplasm and membrane of HCC with Edmondson grade II-III; H: Negative expression of PTEN in HCC with Edmondson grade III-IV.

Figure 2 Expression of PPM1A in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues (Envision, x 200). A-E: Expression of PPM1A in the nucleus of normal liver tissues, hepatitis tissues, cirrhotic liver tissues, paracancerous tissues and Edmondson gradeIHCC, respectively; F: Expression of PPM1A in the nucleus and cytoplasm of grade II HCC; G: Weak expression of PPM1A in the nucleus and cytoplasm of grade II-III HCC, mainly in the cytoplasm; and H: Weak expression of PPM1A in the cytoplasm of grade III-IV HCC.

Figure 3 Expression of P-Smad2 in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues (Envision, x 200). A-E: Expression of P-Smad2 in the nucleus and cytoplasm of normal liver tissues, hepatitis tissues, cirrhotic liver tissues, paracancerous tissues and Edmondson gradeIHCC, respectively; F-H: Expression of P-Smad2 in the nucleus of Edmondson grade II, II-III and III-IV HCC, respectively.