Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome

Figure 1 Pain intensity ratings (100 mm VAS) during tonic rectal (A) and tonic somatic (B) stimulation in non-hypersensitive and hypersensitive IBS patients and in healthy controls. Hypersensitivity is defined by the 95% confidence interval of healthy controls. Means (symbol), 95% confidence intervals (whisker) are shown.

Figure 2 Change in rectal pain intensity scored on a VAS 0-100 during heterotopic stimulation in IBS subgroups and controls. Means (symbol), 95% confidence intervals (whisker) are shown in patients hypersensitive or not to tonic rectal (A) and both tonic rectal and somatic (B) stimulation. Hypersensitivity is defined by the 95% confidence interval of healthy controls.