Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues

Figure 1 Immunohistochemical staining of colorectal adenocarcinoma tissues using KL - 6 antibody (×200). A: Positive staining in the apical membrane; B: positive staining in the circumferential membrane; C: positive staining in the apical membrane and cytoplasm; D: positive staining in the circumferential membrane and cytoplasm.

Figure 2 Kaplan - Meier curves for overall survival rates of patients with colorectal adenocarcinoma. Patients with KL - 6 expression in the circumferential membrane and/or cytoplasm (solid line, group C, n = 46), in the apical membrane (dashed line, group A, n = 29) and without KL - 6 staining (dotted line, group N, n = 5) were followed up for more than 70 mo. Two of 82 patients were excluded from the data analysis as described in Materials and Methods.

Figure 3 Immunohistochemical staining of metastatic lymph node and liver tissues using KL-6 antibody (×200). A:Positive KL-6 expression in a metastatic lymph node; B: positive KL-6 expression in metastatic liver tissues.