Expression of β-catenin in hepatocellular carcinoma

Figure 1 Constitutive expression of β-catenin in normal bile ducts. Membranous expression is conspicuous in normal bile ducts and newly formed bile ducts (arrow heads), but no expression is observed in normal hepatocytes.

Figure 2 Membranous expression. Membranous expression is conspicuous in tumor cell membranes. This case is moderately-differentiated HCC.

Figure 3 Nuclear expression. Nuclear expression is encountered in the poorly-differentiated HCC (arrows). Most cells co-expressed β-catenin in the cytoplasm.

Figure 4 Localization of β-catenin expression in cell level. M: membranous, M+C: membranous and cytoplasmic, M+N: membranous and nuclear, M+N+C: membranous, cytoplasmic, and nuclear, C: cytoplasmic.