Effects of fibril- or fixed-collagen on matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 production in the human hepatocyte cell line HLE

Figure 1 Effects of fibril type I collagen in the culture medium on the collagenase activity for type I collagen. Culture dishes were coated with or without type I collagen (10 μg/mL) and type IV collagen (10 μg/mL). For the control, cells were cultured without fibril collagen. ^bP<0.01 vs controls (Cont).

Figure 2 Effects of fibril type IV collagen in the culture medium on collagenase activity for type I collagen. Culture dishes were coated with or without type I collagen (10 μg/mL) and type IV collagen (10 μg/mL). For the control, cells were cultured without fibril collagen. ^bP<0.01 vs controls (Cont).

Figure 3 Effects of fibril type I (dotted bar) or type IV (filled bar) collagen on matrix metalloproteinase-1 (MMP-1) production. For the control, cells were cultured without fibril collagen. ^aP<0.05; ^bP<0.01; ^dP<0.001 vs controls (Cont).

Figure 4 Effects of fibril type I (dotted bar) or type IV (filled bar) collagen on tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) production. For the control(Cont), cells were cultured without fibril collagen.

Figure 5 Effect of the coating concentrations of type I collagen on matrix metalloproteinase-1 (MMP-1) (A) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) (B) production. For the control, cells were cultured on non-coating dishes. ^bP<0.01 vs controls (Cont).