Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Jan 21, 2027; 33(3): 124070
Published online Jan 21, 2027. doi: 10.3748/wjg.124070
Published online Jan 21, 2027. doi: 10.3748/wjg.124070
Body surface area-indexed residual pancreatic volume predicts early new-onset diabetes after acute necrotizing pancreatitis: Multivariable model evaluation
Cheng-Cheng Tian, Cui Hu, Xing-Yu Liu, Yuan-Yuan Shen, Yu-Mei Wu, Li-Xue Zhang, Qiao Mei, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Co-first authors: Cheng-Cheng Tian and Cui Hu.
Author contributions: Tian CC and Hu C contribute equally to this study as co-first authors; Mei Q is the corresponding author; Mei Q was the first to propose the study concept; Mei Q, Tian CC, and Hu C performed all clinical and data management procedures; Mei Q and Tian CC designed the research study; Tian CC, Hu C, Liu XY, and Shen YY performed the research; Tian CC, Wu YM, and Zhang LX analyzed the data; Tian CC and Hu C wrote the manuscript; Mei Q reviewed the paper; all authors have read and approved the final manuscript.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Institutional review board statement: This study was conducted with approval from the Institutional Review Board and Ethics Committee of the First Affiliated Hospital of Anhui Medical University (approval No. PJ 2023-12-18).
Informed consent statement: The requirement for informed consent was waived by the Institutional Review Board due to the retrospective nature of the study and the use of anonymized clinical data.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Qiao Mei, MD, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. meiqiao@ahmu.edu.cn
Received: June 5, 2026
Revised: June 26, 2026
Accepted: July 27, 2026
Published online: January 21, 2027
Processing time: 162 Days and 7 Hours
Revised: June 26, 2026
Accepted: July 27, 2026
Published online: January 21, 2027
Processing time: 162 Days and 7 Hours
Core Tip
Core Tip: Acute necrotizing pancreatitis (ANP) is often followed by new-onset diabetes (NOD), but reliable tools for early risk stratification are still lacking. We obtained body surface area-indexed residual pancreatic volume (RPV/BSA) from follow-up contrast-enhanced computed tomography performed during the convalescent phase of ANP, and determined NOD status at 3-6 months after disease onset. RPV/BSA exhibited a clear linear inverse relationship with early NOD and emerged as an independent protective factor. A combined model incorporating RPV/BSA, age, peak blood glucose, and bedside index for severity in acute pancreatitis score offered the best overall clinical performance for identifying patients at elevated risk of early NOD.