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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2026; 32(7): 116463
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.116463
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.116463
Endoscopic ultrasound in early gastric cancer: Diagnostic accuracy and Tis/T1a lesion over staging risks
Xue-Yan Qiao, Ge Wen, Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Xue-Yan Qiao, Department of Ultrasound, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China
Ze-Hua Li, Shi-Yong Lin, Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510050, Guangdong Province, China
Co-first authors: Xue-Yan Qiao and Ze-Hua Li.
Co-corresponding authors: Shi-Yong Lin and Ge Wen.
Author contributions: Qiao XY and Li ZH prepared the manuscript draft, they contributed equally to this article, they are the co-first authors of this manuscript; Qiao XY, Li ZH and Lin SY collected and analyzed data; Lin SY and Wen G provided research support and revised the manuscript; Lin SY and Wen G designed the research, they contributed equally to this article, they are the co-corresponding authors of this manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82572175 and No. 82172012.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Sun Yat-sen University Cancer Center, approval No. SL-B2025-755-01.
Informed consent statement: All participants were already asked to give signed informed consent before the operation. So, when this retrospective study was checked by the ethics committee, another informed consent was exempt.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ge Wen, MD, Chief Physician, Department of Medical Imaging, Nan
Received: November 12, 2025
Revised: November 28, 2025
Accepted: December 22, 2025
Published online: February 21, 2026
Processing time: 86 Days and 13 Hours
Revised: November 28, 2025
Accepted: December 22, 2025
Published online: February 21, 2026
Processing time: 86 Days and 13 Hours
Core Tip
Core Tip: This study demonstrates that gastric ulceration is a major independent risk factor contributing to the over staging of Tis/T1a early gastric cancer by endoscopic ultrasound (EUS). The presence of ulceration markedly reduces the sensitivity of EUS (41.25%) and underscores the need for careful interpretation of EUS findings in ulcer-associated lesions to avoid unnecessary or inappropriate overtreatment.