Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2026; 32(7): 114773
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.114773
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.114773
New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis
Xue-Tao Zhang, Xian-Cheng Chen, Tao Gao, Ming Chen, Zhang-Hua Zhu, Bei-Yuan Zhang, Wen-Kui Yu, Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Hao Zhu, Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Co-first authors: Xue-Tao Zhang and Hao Zhu.
Co-corresponding authors: Bei-Yuan Zhang and Wen-Kui Yu.
Author contributions: Zhang BY and Yu WK designed the study and revised the manuscript, they contributed equally to this manuscript and are co-corresponding authors; Zhang XT and Zhu H collected the data and prepared the manuscript, they contributed equally to this manuscript and are co-first authors; Chen XC and Gao T assisted with data analysis and revised the manuscript; Chen M and Zhu ZH secured funding and revised the manuscript. All authors contributed to the study and approved the final manuscript.
Supported by Jiangsu Provincial Health Commission, No. BJ24037.
Institutional review board statement: This study received ethical approval from the Ethics Committee of Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School (approval No. 2025-0786-01). The study was conducted in accordance with the ethical standards outlined in the Declaration of Helsinki.
Informed consent statement: As this was a retrospective study, the requirement for written informed consent was waived by the ethics committee. All patient data were anonymized to protect privacy.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data supporting the findings of this study are available from the corresponding author upon reasonable request and subject to compliance with institutional data sharing policies.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Kui Yu, MD, PhD, Chief, Professor, Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China.
Received: October 10, 2025
Revised: November 17, 2025
Accepted: December 29, 2025
Published online: February 21, 2026
Processing time: 130 Days and 3.5 Hours
Revised: November 17, 2025
Accepted: December 29, 2025
Published online: February 21, 2026
Processing time: 130 Days and 3.5 Hours
Core Tip
Core Tip: The relationship between organ failure (OF) patterns and mortality in severe acute pancreatitis (AP) remains controversial. In this retrospective cohort of 151 patients with severe AP, we found that, after adjusting for initial multi-OF, the duration of OF, and infected pancreatic necrosis, the occurrence of new-onset OF - especially new-onset multi-OF - significantly increased both in-hospital and 90-day mortality rates. This novel perspective expands the theoretical framework linking OF patterns to adverse outcomes in AP and may prove pivotal for future pancreatitis grading systems and the design of related clinical trials.