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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2026; 32(7): 111478
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.111478
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.111478
Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy
Jeongyeon An, Kyung-Hee Kim, Min-Kyung Yeo, Department of Pathology, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Jeongyeon An, Jun Young Heo, Min-Kyung Yeo, System Network Inflammation Control Research Center, Chungnam National University, Daejeon 35015, South Korea
So-Hyun Ahn, Department of Psychiatry, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Jun Young Heo, Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Jun Young Heo, Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Author contributions: An J and Ahn SH contributed equally to this manuscript and are co-first authors. An J and Yeo MK contributed to the resources, data curation, conceptualization and validation, supervision, writing - original draft, and writing - review and editing; Kim KH and Yeo MK participated in the formal analysis; Ahn SH, Heo JH, and Yeo MK contributed to the funding, supervision and project administration. All authors have read and agreed to the published version of the manuscript.
Supported by Korea Health Technology R&D Project Through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Republic of Korea, No. RS-2020-KH088690; and National Research Foundation of Korea Grants funded by the Korean Government (MSIT), No. RS-2024-00406568 and No. RS-2023-00210264.
Institutional review board statement: This retrospective study was approved by the Institutional Review Board of Chungnam National University Hospital (No. CNUH IRB 2024-01-019-001).
Informed consent statement: This research was approved by the Institutional Review Board of Chungnam National University Hospital with a waiver of informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data presented in this study are available on request from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min-Kyung Yeo, MD, PhD, Associate Professor, Department of Pathology, Chungnam National University School of Medicine, Munwha-ro 266, Jung-gu, Daejeon 35015, South Korea. mkyeo83@gmail.com
Received: July 1, 2025
Revised: August 15, 2025
Accepted: December 29, 2025
Published online: February 21, 2026
Processing time: 220 Days and 14.3 Hours
Revised: August 15, 2025
Accepted: December 29, 2025
Published online: February 21, 2026
Processing time: 220 Days and 14.3 Hours
Core Tip
Core Tip: This study examined temporal trends, clinicopathological features, and survival outcomes in post-cholecystectomy gallbladder cancer to identify risk factors for early detection and management. In this single-institutional study, our findings may be limited but still provide insights. Age, hypertension, cholangitis, and serological markers including total cholesterol, triglyceride, albumin were risk factors for cancer and related to survival outcomes. Pathological features, such as tumor budding, tumor size, and poorly cohesive or undifferentiated components were correlated with worse prognosis. These findings emphasize the value of early identification of high-risk profiles and the prognostic markers of gallbladder cancer.