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World J Gastroenterol. Dec 21, 2026; 32(47): 124712
Published online Dec 21, 2026. doi: 10.3748/wjg.124712
Published online Dec 21, 2026. doi: 10.3748/wjg.124712
Clinical efficacy and mechanisms of Astragalus membranaceus, active components, and herbal formulas for chronic atrophic gastritis
Yu-Lian Tong, Qi-Yan Bian, The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Hong-Xin Zheng, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Jing-Dong Xiao, Party Committee Office, Affiliated Hospital of Liaoning University of Tra
Co-corresponding authors: Hong-Xin Zheng and Jing-Dong Xiao.
Author contributions: Tong YL and Bian QY wrote the entire manuscript; Xiao JD and Zheng HX revised and reviewed the final manuscript, and both authors contribute equally to this study as co-corresponding authors. All authors approved the final version to publish.
AI contribution statement: AI tools, specifically DeepSeek-V4-Flash, were used solely for language polishing and formatting assistance. No AI tool was used to generate research data, interpret results, or formulate conclusions. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the accuracy, originality, and integrity of the manuscript.
Supported by National Science and Technology Major Project, No. 2024ZD0521002; General Program of the National Natural Science Foundation of China, No. 82074296; Construction Project of Inheritance Studios of Famous Chinese Medicine Experts in China, No. [2022]75; and Innovation Team Project of Traditional Chinese Medicine of Liaoning Province, No. LNZYYCXTD-CCCX-003.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Hong-Xin Zheng, PhD, Professor, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang 110032, Liaoning Province, China. zhenghx2002@126.com
Received: June 23, 2026
Revised: July 25, 2026
Accepted: August 18, 2026
Published online: December 21, 2026
Processing time: 127 Days and 3.7 Hours
Revised: July 25, 2026
Accepted: August 18, 2026
Published online: December 21, 2026
Processing time: 127 Days and 3.7 Hours
Core Tip
Core Tip: Chronic atrophic gastritis carries the risk of malignant transformation into gastric cancer, posing a severe threat to patient health. Astragalus membranaceus and its herbal formulas have demonstrated remarkable efficacy in the treatment of chronic atrophic gastritis. The underlying mechanisms primarily involve eradication of Helicobacter pylori, modulation of immunity, alleviation of inflammatory responses, mitigation of oxidative stress, and protection of the gastric mucosa.