Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2026; 32(47): 122777
Published online Dec 21, 2026. doi: 10.3748/wjg.122777
Published online Dec 21, 2026. doi: 10.3748/wjg.122777
Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism
Li-Fang Chen, Su-Feng Luo, Ya Luo, Qin-Rong Li, Department of Gastroenterology, Xishu
Yuan-Yuan Chen, Zi-Qing Xu, Sha-Sha Liu, Xiao-Rong Wang, Department of Gastroenterology, Dai Medicine Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong 666100, Yunnan Province, China
Fei-Tian Min, Wei-Bo Wen, Ning Wang, Huan-Tian Cui, The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, Yunnan Province, China
Xia Chen, Department of Spleen and Gastroenterology, Yunnan Provincial Hospital of Tra
Co-first authors: Li-Fang Chen and Yuan-Yuan Chen.
Co-corresponding authors: Huan-Tian Cui and Xiao-Rong Wang.
Author contributions: Chen LF and Chen YY performed the research and wrote the original draft, contributed equally to this article as co-first authors; Chen LF and Cui HT acquired funding; Min FT, Wen WB and Luo SF developed methodology; Luo Y, Li QR and Xu ZQ performed the experiments, acquired and analyzed data; Li QR, Xu ZQ, Liu SS, Chen X and Wang N interpreted the data; Cui HT and Wang XR designed the research study, participated in review and editing, contributed equally to this article as co-corresponding authors; all authors approved the final version of the article.
AI contribution statement: The entirety or any portion of the main text of the manuscript was not AI-generated. The AI tool was not used for language polishing, translation, or writing assistance of the manuscript. The AI tool did not participate in design of the study or interpretation of its results. This study was designed by our team. No image in the manuscript was generated by AI.
Supported by 2025 Yunnan Provincial International Science and Technology Commissioner (Individual) Certification Program, No. 202503AK140045; and Open Research Fund Program of Yunnan Key Laboratory for Dai and Yi Medicines (Yunnan University of Chinese Medicine), No. 2025ZD2502.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethical Review Committee of Animal Experiments in Yunnan University of Chinese Medicine, No. YNUCM-XMSB-G-20250280.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data in the research will be made available on request.
Corresponding author: Huan-Tian Cui, PhD, Post Doctoral Researcher, Principal Investigator, Senior Researcher, The First School of Clinical Medicine, Yunnan University of Chinese Medi
Received: April 28, 2026
Revised: June 16, 2026
Accepted: September 22, 2026
Published online: December 21, 2026
Processing time: 182 Days and 21.1 Hours
Revised: June 16, 2026
Accepted: September 22, 2026
Published online: December 21, 2026
Processing time: 182 Days and 21.1 Hours
Core Tip
Core Tip: Ya-Han-Lu-Duan (YHLD) decoction exerts a significant protective effect against colitis-associated colorectal cancer. YHLD remodels the immunosuppressive tumor microenvironment by suppressing cancer-associated fibroblast activation and myeloid-derived suppressor cells infiltration. YHLD is likely to inhibit ALOX12-mediated and PTGS2-mediated arachidonic acid metabolism in cancer-associated fibroblasts and myeloid-derived suppressor cells through multi