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World J Gastroenterol. Dec 21, 2026; 32(47): 120094
Published online Dec 21, 2026. doi: 10.3748/wjg.v32.i47.120094
Published online Dec 21, 2026. doi: 10.3748/wjg.v32.i47.120094
Jejunal diverticula bleeding: A challenging diagnosis entity
Roberto Anaya-Prado, Ana V Dominguez-Soto, Katia N Osorio-Medina, Roberto I Ortiz-Vera, Jacqueline Soto-Hintze, Bruno Reyna-Rodriguez, Department of Research, School of Medicine and Health Sciences, Tecnologico de Monterrey, Zapopan 45116, Jalisco, Mexico
Roberto Anaya-Prado, Ana V Dominguez-Soto, Katia N Osorio-Medina, Roberto I Ortiz-Vera, Jacqueline Soto-Hintze, Bruno Reyna-Rodriguez, Department of Surgery, School of Medicine and Health Sciences, Tecnologico de Monterrey, Zapopan 45116, Jalisco, Mexico
Roberto Anaya-Prado, Ana V Dominguez-Soto, Katia N Osorio-Medina, Roberto I Ortiz-Vera, Daniel Gonzalez-Martinez, Roberto Anaya-Fernández, Rafael Portillo-Mendez, Michelle Marie Anaya-Fernández, Consuelo C Azcona-Ramirez, Miguel A Guerrero-Palomera, Alma J Peña-Cuellar, Jacqueline Soto-Hintze, Bruno Reyna-Rodriguez, Direction of Research and Education, Corporate Hospitals Puerta de Hierro, Zapopan 45116, Jalisco, Mexico
Roberto Anaya-Fernández, Department of Neurosurgery, Hospital Dr. Valentin Gomez Farias, ISSSTE, Zapopan 45100, Jalisco, Mexico
Miguel A Guerrero-Palomera, Department of Surgery, Hospital Civil de Tepic Dr Antonio González Guevara, Tepic 63000, Nayarit, Mexico
Author contributions: Anaya-Prado R, Dominguez-Soto AV, Osorio-Medina KN, Ortiz-Vera RI, Gonzalez-Martinez D, and Anaya-Fernández R performed research and analyzed data; Portillo-Mendez R, Anaya-Fernández MM, Azcona-Ramirez CC, Guerrero-Palomera MA, Peña-Cuellar AJ, Soto-Hintze J, and Reyna-Rodriguez B contributed new analytic tools; Anaya-Fernández R, Portillo-Mendez R, Anaya-Fernández MM, Azcona-Ramirez CC, Guerrero-Palomera MA, Peña-CuellarAJ, Soto-Hintze J, and Reyna-Rodriguez B wrote the paper; all authors contributed equally to the conception, literature review, drafting, overall content, and revision of the article; all authors approved the version of the manuscript to be published.
Conflict-of-interest statement: All authors have declared that no competing interests exist.
Corresponding author: Roberto Anaya-Prado, MD, PhD, Professor Department of Research, School of Medicine and Health Sciences, Tecnologico de Monterrey, Blvd Puerta de Hierro, No. 5150 Int 201B. Fraccionamiento Puerta de Hierro, Zapopan 45116, Jalisco, Mexico.
Received: February 24, 2026
Revised: April 2, 2026
Accepted: May 6, 2026
Published online: December 21, 2026
Processing time: 255 Days and 9.5 Hours
Revised: April 2, 2026
Accepted: May 6, 2026
Published online: December 21, 2026
Processing time: 255 Days and 9.5 Hours
Core Tip
Core Tip: Jejunal diverticula (JD) predominantly affects older patients, with higher prevalence observed in Western populations. Most cases are discovered incidentally during imaging studies or autopsy, as clinical manifestations ranging from abdominal pain to melena are often nonspecific and may mimic other gastrointestinal conditions. The pathogenesis of JD is multifactorial, involving increased intraluminal pressure, bowel wall weakness, gut dysbiosis, low fiber intake, and possible genetic predispositions. Jejunal diverticulosis is frequently misdiagnosed due to vague presentation and diagnostic limitations. Therefore, early recognition and appropriate management are essential to reduce morbidity and prevent life-threatening outcomes.