Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 14, 2026; 32(46): 121360
Published online Dec 14, 2026. doi: 10.3748/wjg.121360
Published online Dec 14, 2026. doi: 10.3748/wjg.121360
Development and validation of a clinical data-based diagnostic model for neonatal intrahepatic cholestasis caused by citrin deficiency
Tao Jiang, Xiao-Mei Qin, Shuang-Jie Li, Na Liu, Wen-Xian Ouyang, Department of Hepatopathy Center, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha 410007, Hunan Province, China
Yuan-Wei Liu, Department of Pediatric Medicine, The First People’s Hospital of Chenzhou, Chenzhou 423000, Hunan Province, China
Song-Xu Peng, Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China
Co-first authors: Tao Jiang and Xiao-Mei Qin.
Co-corresponding authors: Wen-Xian Ouyang and Song-Xu Peng.
Author contributions: Jiang T and Qin XM participated in the conception and design of the study and were involved in the acquisition, analysis, or interpretation of data; Jiang T wrote the manuscript; Li SJ, Liu YW and Liu N designed the research study and performed the research; Ouyang WX and Peng SX accessed and verified the study data. All authors critically reviewed and provided final approval of the manuscript. All authors were responsible for the decision to submit the manuscript for publication. The collaboration and sharing of tasks crucial to the conduction and completion of the study by Jiang T and Qin XM underlie their designation as co-first authors. The equal contributions of Ouyang WX and Peng SX formed the logistical core of the study and were critical for its ultimate publication, underlying their merit as co-corresponding authors.
AI contribution statement: I assume full responsibility and accountability for the integrity, accuracy, originality, and scientific validity of the manuscript and all submitted materials. And I do not use artificial intelligence tools in the preparation of the manuscript and answering the reviewers.
Supported by Hunan Provincial Clinical Research Center for Pediatric Liver Diseases, Technology Department of Hunan Province, No. 2020SK4002; and Clinical Research (Translation) Center of Hunan Children’s Hospital.
Institutional review board statement: The study was approved by the Ethics Committee of Hunan Children’s Hospital (No. KS2026-173).
Informed consent statement: The requirement for informed consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The dataset generated and analyzed during the current study is available from the corresponding author on reasonable request.
Corresponding author: Wen-Xian Ouyang, MD, Department of Hepatopathy Center, The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), No. 86 of Ziyuan Road, Changsha 410007, Hunan Province, China. 3441325922@qq.com
Received: March 24, 2026
Revised: May 22, 2026
Accepted: August 20, 2026
Published online: December 14, 2026
Processing time: 210 Days and 23.6 Hours
Revised: May 22, 2026
Accepted: August 20, 2026
Published online: December 14, 2026
Processing time: 210 Days and 23.6 Hours
Core Tip
Core Tip: This study developed a novel diagnostic model for citrin deficiency-induced neonatal intrahepatic cholestasis based on clinical variables, representing a new approach in the literature. The model’s excellent diagnostic performance suggests that it could significantly assist in clinical decision-making.