Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 7, 2026; 32(41): 121527
Published online Nov 7, 2026. doi: 10.3748/wjg.121527
Published online Nov 7, 2026. doi: 10.3748/wjg.121527
Disentangling true inspection time from therapeutic intervals: Validation of effective withdrawal time as a colonoscopy quality metric
Zi-Ye Peng, Yue Huang, Xiang-Yu Wang, Qi An, Zhao-Yu Yin, Xi-Mo Wang, Zheng-Cun Pei, Medical School, Tianjin University, Tianjin 300072, China
Jia-Xin Li, Xi-Mo Wang, Department of Surgery, Tianjin Third Central Hospital, Tianjin 300110, China
Jia-Xin Li, Central Hospital, Tianjin University, Tianjin 300072, China
Yan-Ru Li, Jia-Yi Sun, Yu-Wei Wang, Xiao Yang, Qi Zhang, Shu-Yi Zhang, Department of Endoscopy, Tianjin Union Medical Center, Tianjin 150300, China
Co-first authors: Zi-Ye Peng and Jia-Xin Li.
Co-corresponding authors: Shu-Yi Zhang and Zheng-Cun Pei.
Author contributions: Peng ZY and Li JX contributed equally to this work as co-first authors; Peng ZY, Li JX and Huang Y analyzed the data and wrote the manuscript; Peng ZY, Li JX, Huang Y, Wang XY, An Q, Yin ZY and Wang XM performed the research; Li YR, Sun JY, Wang YW, Yang X and Zhang Q contributed new reagents and analytic tools; Zhang SY and Pei ZC supervised the study and revised the manuscript as co-corresponding authors; Peng ZY, Li JX, Huang Y, Wang XY, An Q, Yin ZY, Li YR, Sun JY, Wang YW, Yang X, Zhang Q, Wang XM, Zhang SY and Pei ZC designed the research study; all authors have read and approved the final manuscript.
AI contribution statement: During the preparation of this work, the authors used Gemini (Google) to improve the language, readability, and grammatical accuracy of the manuscript and answering-reviewers document. After using this tool, the authors reviewed and edited the content as needed and took full responsibility for the content of the published article. AI tools did not participate in study design, scientific interpretation, data analysis, or decision-making. No AI-generated images were used in this manuscript.
Supported by the Tianjin Health Science and Technology Project, No. TJWJ2025MS017; and the Natural Science Foundation of Tianjin, No. 24JCQNJC01990.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Medical Ethics Committee of Tianjin Union Medical Center (approval No. 2022-C10).
Clinical trial registration statement: Trial registration was not required for this study as it was an observational study and did not involve any clinical interventions.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Zheng-Cun Pei, PhD, Medical School, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, China. peizhengcun@tju.edu.cn
Received: March 27, 2026
Revised: May 13, 2026
Accepted: June 17, 2026
Published online: November 7, 2026
Processing time: 172 Days and 11.5 Hours
Revised: May 13, 2026
Accepted: June 17, 2026
Published online: November 7, 2026
Processing time: 172 Days and 11.5 Hours
Core Tip
Core Tip: Effective withdrawal time (EWT), derived from an artificial intelligence-based system, provides a refined measure of true mucosal inspection by excluding therapeutic and visually obscured phases during colonoscopy. In this study, EWT showed stronger associations with adenoma detection rate and polyp detection rate than standard withdrawal time, along with superior predictive performance. Nonlinear analysis revealed a plateau effect, suggesting that an inspection time of approximately 6-10 minutes may be optimal. EWT may serve as a more precise and clinically actionable quality metric.