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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2026; 32(4): 113647
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.113647
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.113647
Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytes
Ting Gao, Kang-Peng Zhong, Jun-Zhuo Wang, Chun-Xiao Li, Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China
Yi Chen, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Co-first authors: Ting Gao and Kang-Peng Zhong.
Co-corresponding authors: Yi Chen and Chun-Xiao Li.
Author contributions: Li CX and Chen Y conceived of the study; Gao T, Zhong KP, and Wang JZ performed the experiments; Gao T and Zhong KP analyzed the data and wrote the paper; Li CX revised the paper; all authors reviewed and approved the final version of the manuscript.
Supported by the Natural Science Foundation of Zhejiang Province, No. LQ22H030001; the Natural Science Foundation of Ningbo, No. 2024J474; the Ningbo Top Medical and Health Research Program, No. 2023020612; and the Project of Ningbo Leading Medical and Healthy Discipline, No. 2022-S04.
Institutional review board statement: This study did not involve human subjects or living animals.
Institutional animal care and use committee statement: This study does not involve animal research.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data in this study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Xiao Li, PhD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo 315010, Zhejiang Province, China. 11418130@zju.edu.cn
Received: September 1, 2025
Revised: October 24, 2025
Accepted: November 19, 2025
Published online: January 28, 2026
Processing time: 143 Days and 18.1 Hours
Revised: October 24, 2025
Accepted: November 19, 2025
Published online: January 28, 2026
Processing time: 143 Days and 18.1 Hours
Core Tip
Core Tip: Metabolic dysfunction-associated steatotic liver disease (MASLD) denotes a continuum of disorders unified by hepatic steatosis and can affect approximately one quarter of the global population, reaching up to 75% among individuals with obesity. This work seeks to define the functional contribution and mechanism of allyl isothiocyanate (AITC) in miti