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World J Gastroenterol. Oct 21, 2026; 32(39): 122644
Published online Oct 21, 2026. doi: 10.3748/wjg.122644
Published online Oct 21, 2026. doi: 10.3748/wjg.122644
Letter to the Editor: Chaihu-Shugan-San in the treatment of atrophic gastritis
Tamara V Polivanova, Vitaliy A Vshivkov, Clinical Division of Digestive System Pathology in Adults and Children, Federal Research Center (Krasnoyarsk Science Center) of the Siberian Branch of the Russian Academy of Sciences - Scientific Research Institute for Medical Problems of the North, Krasnoyarsk 660022, Russia
Edward V Kasparov, Department of Administration, Federal Research Center (Krasnoyarsk Science Center) of the Siberian Branch of the Russian Academy of Sciences - Scientific Research Institute for Medical Problems of the North, Krasnoyarsk 660022, Russia
Co-corresponding authors: Tamara V Polivanova and Vitaliy A Vshivkov.
Author contributions: Polivanova TV and Vshivkov VA contribute equally to this study as co-corresponding authors; Polivanova TV, Kasparov EV, and Vshivkov VA contributed to writing of the manuscript.
AI contribution statement: No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Tamara V Polivanova, MD, PhD, Professor, Clinical Division of Digestive System Pathology in Adults and Children, Federal Research Center (Krasnoyarsk Science Center) of the Siberian Branch of the Russian Academy of Sciences - Scientific Research Institute for Medical Problems of the North, Partizana Zheleznyaka St 3G, Kra
Received: April 24, 2026
Revised: June 6, 2026
Accepted: June 12, 2026
Published online: October 21, 2026
Processing time: 135 Days and 18 Hours
Revised: June 6, 2026
Accepted: June 12, 2026
Published online: October 21, 2026
Processing time: 135 Days and 18 Hours
Core Tip
Core Tip: In their experimental article, Song et al presented results demonstrating the high efficacy of the traditional Chinese herbal mixture Chaihu-Shugan-San (CSS). They identified specific interactions between CSS components and key targets. Particular emphasis was placed on inhibition of the nuclear factor kappa B signaling pathway by CSS, accompanied by regression of inflammatory and structural changes in the gastric mucosa in N-methyl-N'-nitro-N-nitrosoguanidine-induced atrophic gastritis. Research using this traditional Chinese herbal mixture offers significant potential and a new strategy for the prevention and treatment of atrophic gastritis and gastric cancer.