Genetically influenced pediatric chronic pancreatitis: Radiologic perspectives

doi:10.3748/wjg.122342

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 14, 2026; 32(38): 122342
Published online Oct 14, 2026. doi: 10.3748/wjg.122342

Genetically influenced pediatric chronic pancreatitis: Radiologic perspectives

Buket Daldaban Sarıca, Zehra Filiz Karaman, Derya Altay, Duran Arslan

Buket Daldaban Sarıca, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Kayseri City Training and Research Hospital, Kayseri 38080, Türkiye

Zehra Filiz Karaman, Department of Pediatric Radiology, Erciyes University Faculty of Medicine, Kayseri 38039, Türkiye

Derya Altay, Duran Arslan, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Erciyes University Faculty of Medicine, Kayseri 38039, Türkiye

Author contributions: Daldaban Sarıca B, Filiz Karaman Z, Altay D, and Arslan D conceived and designed the study and collected the data; Daldaban Sarıca B and Arslan D analyzed the data; Daldaban Sarıca B, Altay D, and Arslan D drafted and revised the manuscript; all authors reviewed and approved the final version of the manuscript.

AI contribution statement: Portions of this manuscript were edited using AI-assisted tools solely for language refinement. The authors reviewed all edits and take full responsibility for the manuscript content.

Institutional review board statement: This study was approved by Erciyes University Ethics Committee (No. 2024/261).

Informed consent statement: Given the retrospective design of the study and the use of anonymized medical record data, the requirement for written informed consent was waived by the ethics committee. All procedures were conducted in accordance with institutional ethical standards and the principles of the Declaration of Helsinki.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Data sharing statement: The datasets generated and/or analyzed in the current study are not publicly available due to institutional and ethical restrictions.

Corresponding author: Buket Daldaban Sarıca, MD, Doctor, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Kayseri City Training and Research Hospital, Muhsin Yazıcıoğlu Blvd, Kayseri 38080, Türkiye. buketdaldaban@gmail.com

Received: April 20, 2026
Revised: May 30, 2026
Accepted: July 8, 2026
Published online: October 14, 2026
Processing time: 143 Days and 3 Hours

Core Tip

Core Tip: Although genetic factors constitute a major component of the etiology of pediatric chronic pancreatitis, radiologic phenotypic differences among genetic subtypes remain poorly characterized. In this study, genetically associated pediatric chronic pancreatitis cases were categorized into CFTR, CTRC/PRSS1, and SPINK1 subgroups, and their clinical, biochemical, and cross-sectional imaging findings were compared. These findings suggest that genetic background may contribute to radiologic and biochemical differences in pediatric chronic pancreatitis.