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World J Gastroenterol. Sep 28, 2026; 32(36): 119520
Published online Sep 28, 2026. doi: 10.3748/wjg.119520
Published online Sep 28, 2026. doi: 10.3748/wjg.119520
Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases
Zi-Wei Hou, Academy of Medical Sciences, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Pan Zhang, School of Public Health, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Chen Chen, Department of Neurology, Affiliated Cardiovascular Hospital of Shanxi Medical University, Taiyuan 030024, Shanxi Province, China
Chen Chen, Shanxi Key Laboratory of Heart Failure Precision Medicine, Shanxi Cardiovascular Hospital, Taiyuan 030024, Shanxi Province, China
Co-first authors: Zi-Wei Hou and Pan Zhang.
Author contributions: Hou ZW and Zhang P performed the research, they contributed equally to this article, they are the co-first authors of this manuscript; Chen C designed the study; and all authors have read and approved the final version of the manuscript.
AI contribution statement: We declare that AI tools (specifically DeepSeek) were used only as a writing assistant to optimize language expression and grammar during the drafting process. No AI tools were used to generate the scientific content, original ideas, theoretical framework, literature analysis, or authors’ perspectives.
Supported by the Shanxi Province Chinese Medicine Science and Technology Special Research Project, No. 2024ZYY2A023; and the Integration of Medicine, Engineering, and Basic Medical Sciences Special Project of Shanxi Provincial Health Commission, No. 2025YGYL026.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Chen Chen, PhD, Chief Physician, Department of Neurology, Affiliated Cardiovascular Hospital of Shanxi Medical University, No. 18 Yifen Street, Taiyuan 030024, Shanxi Province, China. chen.chen@sxmu.edu.cn
Received: January 30, 2026
Revised: April 19, 2026
Accepted: May 14, 2026
Published online: September 28, 2026
Processing time: 204 Days and 5.3 Hours
Revised: April 19, 2026
Accepted: May 14, 2026
Published online: September 28, 2026
Processing time: 204 Days and 5.3 Hours
Core Tip
Core Tip: Recent studies have observed functional remodeling of gut microbiota during aging, particularly enhanced lipid metabolism pathways. This article discusses the gut-liver axis and gut-brain axis as potential bridges linking microbial alterations to host aging, with neuroinflammation potentially acting as an integrative hub. Targeting the “microbiota-multi-organ axis-neuroinflammation” network may provide potential directions for future research on healthy aging.