Letter to the Editor: Autophagy related RHEB-CSF1R complex promotes tumor metastasis in pancreatic cancer: Mechanobiological perspective for RHEB-targeted cancer treatment

doi:10.3748/wjg.119393

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 21, 2026; 32(35): 119393
Published online Sep 21, 2026. doi: 10.3748/wjg.119393

Letter to the Editor: Autophagy related RHEB-CSF1R complex promotes tumor metastasis in pancreatic cancer: Mechanobiological perspective for RHEB-targeted cancer treatment

Ilya Klabukov, Yana Sulina, Denis Baranovskii

Ilya Klabukov, Denis Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Kaluzhskaya Oblast’, Russia

Ilya Klabukov, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Kaluzhskaya Oblast’, Russia

Yana Sulina, Department of Obstetrics, Gynecology and Perinatal Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Moskva, Russia

Denis Baranovskii, Institute of Systems Biology and Medicine, Russian University of Medicine, Moscow 117997, Moskva, Russia

Author contributions: Klabukov I conceived and designed the research and wrote the letter; Baranovskii D and Sulina Y analyzed the data; Klabukov I revised the letter.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Corresponding author: Ilya Klabukov, PhD, Associate Professor, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Kaluzhskaya Oblast’, Russia. ilya.klabukov@gmail.com

Received: January 26, 2026
Revised: February 18, 2026
Accepted: March 9, 2026
Published online: September 21, 2026
Processing time: 205 Days and 0.9 Hours

Core Tip

Core Tip: Ras homolog enriched in brain (RHEB)-driven pathways promote tumor aggressiveness by phosphorylating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin, which influences tumor cell mechanosensing and interaction with the extracellular matrix. Advanced therapeutic strategies for treating solid tumors could target RHEB-mediated signaling.