Letter to the Editor: Prospects for applying the results of studying the Sonic Hedgehog pathway to the diagnosis of metabolic dysfunction-associated steatohepatitis

doi:10.3748/wjg.120070

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 14, 2026; 32(34): 120070
Published online Sep 14, 2026. doi: 10.3748/wjg.120070

Letter to the Editor: Prospects for applying the results of studying the Sonic Hedgehog pathway to the diagnosis of metabolic dysfunction-associated steatohepatitis

Vladislav V Tsukanov, Alexander V Vasyutin, Edward V Kasparov, Julia L Tonkikh

Vladislav V Tsukanov, Alexander V Vasyutin, Edward V Kasparov, Julia L Tonkikh, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk 660022, Russia

Author contributions: Tsukanov VV, Vasyutin AV, Kasparov EV, and Tonkikh JL contributed to this paper; Tsukanov VV designed the overall concept and outline of the manuscript; Vasyutin AV wrote the original draft; Tonkikh JL reviewed the literature; Tsukanov VV and Kasparov EV reviewed and edited the manuscript; Tsukanov VV, Vasyutin AV, and Kasparov EV participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Vladislav V Tsukanov, MD, PhD, Full Professor, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, 3-G Partizan Zheleznyak Street, Krasnoyarsk 660022, Russia. gastro@impn.ru

Received: February 14, 2026
Revised: April 2, 2026
Accepted: May 11, 2026
Published online: September 14, 2026
Processing time: 186 Days and 20.3 Hours

Core Tip

Core Tip: The Sonic Hedgehog (SHH) signaling plays an important role in the development of animals by regulating organogenesis, tissue homeostasis, and regeneration. In a number of studies, it has been established that SHH dysregulation is associated with progression of metabolic dysfunction-associated steatohepatitis. In this regard, Han et al, who combined modern fundamental ideas with a high-class histological examination of the liver and established a strong correlation of SHH with steatosis, inflammation and liver fibrosis in metabolic dysfunction-associated steatohepatitis patients, certainly deserve approval and further development of their research.