From polymorphism to phenotype: FADS2 rs174538, fatty acid signatures and disease activity in Japanese Crohn’s disease

doi:10.3748/wjg.117562

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 7, 2026; 32(33): 117562
Published online Sep 7, 2026. doi: 10.3748/wjg.117562

From polymorphism to phenotype: FADS2 rs174538, fatty acid signatures and disease activity in Japanese Crohn’s disease

Si-Rui Wang, Ting-Lan Cao, Hui-Zhong Jiang

Si-Rui Wang, Ting-Lan Cao, Hui-Zhong Jiang, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Author contributions: Wang SR wrote the original draft; Cao TL and Jiang HZ contributed to conceptualization, writing, reviewing and editing; Wang SR, Jiang HZ, and Cao TL participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Hui-Zhong Jiang, PhD, Professor, Researcher, Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Beijing 100700, China. jianghz93@126.com

Received: December 10, 2025
Revised: February 14, 2026
Accepted: March 9, 2026
Published online: September 7, 2026
Processing time: 242 Days and 12.4 Hours

Core Tip

Core Tip: FADS variants shape polyunsaturated fatty acids (PUFAs) fatty-acid profiles, but it is uncertain whether this matters in Crohn’s disease (CD). Matsuzawa et al bring this question into a CD cohort by linking rs174538 to stable erythrocyte membrane fatty-acid patterns and desaturase indices. Notably, the relationship between an erythrocyte delta-6 desaturase index and CD Activity Index was present only in rs174538 wild-type carriers and disappeared in mutant carriers. This highlights that the same metabolic marker can carry different clinical information depending on genetic background, offering a clearer framework for interpreting lipid biomarkers and inconsistent omega-3 (n-3) PUFAs trial results in inflammatory bowel disease.