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World J Gastroenterol. Sep 7, 2026; 32(33): 116857
Published online Sep 7, 2026. doi: 10.3748/wjg.116857
Published online Sep 7, 2026. doi: 10.3748/wjg.116857
Inflammatory markers as bridges to the mind in postoperative intestinal tumor recovery
Iyad A Issa, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Abu Dhabi 41475, United Arab Emirates
Taly Issa, Medical School, University of Nicosia, Nicosia 24005, Cyprus
Author contributions: Issa IA designed the overall concept and outline of the manuscript; Issa T contributed to the discussion and design of the manuscript; Issa IA and Issa T contributed to the writing, and editing the manuscript, illustrations, and review of literature; all authors have read and approved the final manuscript.
AI contribution statement: The authors only used Claude AI solely for linguistic revision and language polishing of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Iyad A Issa, MD, Doctor, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Marina Village, Villa No. A21, Abu Dhabi 41475, United Arab Emirates. iyadissa71@gmail.com
Received: November 24, 2025
Revised: December 18, 2025
Accepted: February 3, 2026
Published online: September 7, 2026
Processing time: 260 Days and 8.8 Hours
Revised: December 18, 2025
Accepted: February 3, 2026
Published online: September 7, 2026
Processing time: 260 Days and 8.8 Hours
Core Tip
Core Tip: Wei et al transform routine inflammatory markers into psychological risk stratification tools by demonstrating that neutrophil-to-lymphocyte ratio > 7.0 and albumin-to-fibrinogen ratio < 12.0 mechanistically predict postoperative depression and anxiety in intestinal tumor patients. This paradigm shift enables early identification of vulnerable patients using existing clinical infrastructure, facilitating integrated physical-mental rehabilitation that addresses the biological roots of postoperative psychological distress rather than treating mind and body as separate domains.