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World J Gastroenterol. Aug 28, 2026; 32(32): 120450
Published online Aug 28, 2026. doi: 10.3748/wjg.120450
Published online Aug 28, 2026. doi: 10.3748/wjg.120450
Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis
Zi-Yun Zhuo, Xiao-Ya Guo, Ming-Mei Shang, Shan Xue, Zhi-Guo Guo, Department of Gas
Xiao-Ming Liu, Department of Gastroenterology, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, Henan Province, China
Lei Peng, Department of Biological and Food Engineering, Suzhou University, Suzhou 234000, Anhui Province, China
Co-first authors: Zi-Yun Zhuo and Xiao-Ya Guo.
Co-corresponding authors: Lei Peng and Zhi-Guo Guo.
Author contributions: Zhuo ZY and Guo XY performed data acquisition and initial manuscript preparation as co-first authors; Zhuo ZY, Guo XY, Liu XM, and Shang MM conducted experimental procedures and data analysis; Xue S and Guo XY did visualization and verification; Peng L and Guo ZG did manuscript revision and result interpretation as co-corresponding authors; Guo ZG accomplished study design, data acquisition, funding procurement, and research supervision. All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82400621; Anhui Provincial Health Science and Technology Project, No. AHWJ2024Aa20059; Anhui Province Traditional Chinese Medicine Inheritance Innovation Project, No. 2024CCCX271; and Anhui Province Education Department Project, No. 2023jyxm1156.
Institutional animal care and use committee statement: All animal-related experimental procedures were reviewed and approved by the Ethics Committee of Suzhou Hospital of Anhui Medical University, No. KY-YJ-2024-006.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author.
Corresponding author: Zhi-Guo Guo, MD, Professor, Department of Gastroenterology, Suzhou Hospital of Anhui Medical University, No. 616 Bianyangsan Road, Suzhou 234000, Anhui Province, China. guozhiguo@ahmu.edu.cn
Received: February 28, 2026
Revised: April 23, 2026
Accepted: June 22, 2026
Published online: August 28, 2026
Processing time: 158 Days and 14.4 Hours
Revised: April 23, 2026
Accepted: June 22, 2026
Published online: August 28, 2026
Processing time: 158 Days and 14.4 Hours
Core Tip
Core Tip: Extracts of Gleditsia sinensis Lam. thorn (EGST) ameliorates dextran sulfate sodium-induced ulcerative colitis. EGST inhibited the ferroptosis of erastin-induced Caco-2 cells. EGST regulates nitric oxide and reactive oxygen species inhibit lipid peroxidation. EGST activated the peroxisome proliferator-activated receptor gamma/glutathione peroxidase 4 signaling pathway and inhibit ferroptosis. We report for the first time that EGST alleviates colitis in mice by regulating taurohyodeoxycholic acid.