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World J Gastroenterol. Aug 28, 2026; 32(32): 119375
Published online Aug 28, 2026. doi: 10.3748/wjg.v32.i32.119375
Published online Aug 28, 2026. doi: 10.3748/wjg.v32.i32.119375
Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases
Tian-Shuai Zhang, Xiao-Ming Zhu, Rong-Bo Wen, Le-Qi Zhou, Hai-Feng Gong, En-Da Yu, Hao Wang, Li-Qiang Hao, Guan-Yu Yu, Wei Zhang, Department of Colorectal Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China
Gang Li, Department of the Hepatobiliary and Pancreatic Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China
Wei-Ping Zhou, Department of Hepatic Surgery, The Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200433, China
Co-first authors: Tian-Shuai Zhang and Xiao-Ming Zhu.
Co-corresponding authors: Guan-Yu Yu and Wei Zhang.
Author contributions: Zhang TS and Zhu XM contributed to formal analysis, visualization, and writing-original draft as co-first authors; Wen RB, Zhou LQ, and Gong HF contributed to the investigation; Yu ED, Wang H, Li G, Zhou WP, and Hao LQ contributed to data curation; Yu GY and Zhang W contributed to conceptualization, funding acquisition, project administration, and writing-review and editing as co-corresponding authors. All authors approved the final version to publish.
Supported by National Natural Science Foundation of China, No. 82473439 and No. 82503486; Shanghai “Rising Stars of Medical Talents” Youth Development Program of the Shanghai Municipal Health Commission, China, No. 2024-70; Naval Medical University “Deep Blue” Project Talent Program; the First Affiliated Hospital of Naval Medical University Special Project for Basic Medical Research, China, No. 2023QD003 and No. 2023PY04; the First Affiliated Hospital of Naval Medical University Special Project for Clinical Research, China, No. 2024 LYA02; and Shanghai Science and Technology Plan Project, No. 25SF1901500.
Institutional review board statement: This study was approved by the Ethic Committee of Changhai Hospital, No. CHEC2017-235.
Informed consent statement: Written informed consent was obtained from all participants. All patient data were anonymized prior to analysis to ensure confidentiality.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data are available on reasonable request from the corresponding author.
Corresponding author: Wei Zhang, MD, PhD, Chief, Professor, Department of Colorectal Surgery, Shanghai Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. weizhang2000cn@163.com
Received: January 28, 2026
Revised: March 31, 2026
Accepted: May 29, 2026
Published online: August 28, 2026
Processing time: 187 Days and 8.3 Hours
Revised: March 31, 2026
Accepted: May 29, 2026
Published online: August 28, 2026
Processing time: 187 Days and 8.3 Hours
Core Tip
Core Tip: The best simultaneous resection strategy for patients with colorectal cancer liver metastases remains controversial. In this study, we innovatively propose a laparoscopic hybrid surgery (LHS) approach for simultaneous resection of colorectal cancer liver metastases. Compared with totally open surgery, the incidence of complications in the LHS group was significantly lower (10.4% vs 20.5%, P = 0.022). Patients treated with LHS had a shorter postoperative length of stay, earlier postoperative intake of liquids, less blood loss, and similar survival outcomes (overall survival, P = 0.464; disease-free survival, P = 0.838) to those treated with totally open surgery.