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World J Gastroenterol. Aug 28, 2026; 32(32): 117644
Published online Aug 28, 2026. doi: 10.3748/wjg.117644
Published online Aug 28, 2026. doi: 10.3748/wjg.117644
Letter to the Editor: Prevention and management of metabolic dysfunction-associated steatotic liver disease: Insights from Egypt and implications for China
Xiao-Lin Liu, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Jian-Gao Fan, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Author contributions: Liu XL designed and wrote the manuscript; Fan JG designed and approved the final manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Noncommunicable Chronic Disease-National Science and Technology Major Project of China, No. 2023ZD0508700; National Natural Science Foundation of China, No. 81900508; and Suzhou Basic Research General Project, No. SSD2024042.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Jian-Gao Fan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. fattyliver2004@126.com
Received: December 17, 2025
Revised: January 28, 2026
Accepted: March 2, 2026
Published online: August 28, 2026
Processing time: 227 Days and 17.2 Hours
Revised: January 28, 2026
Accepted: March 2, 2026
Published online: August 28, 2026
Processing time: 227 Days and 17.2 Hours
Core Tip
Core Tip: This article provides a comparative analysis of metabolic dysfunction-associated steatotic liver disease between Egypt, a high-prevalence country with resource constraints, and China, which exhibits advanced diagnostic and therapeutic capabilities with similar epidemic trend. It highlights key divergences in epidemiology, viral hepatitis interactions, and gender distribution, while identifying shared metabolic drivers and nutrition transition. The synthesis underscores the necessity for integrated, context-sensitive public health strategies that combine early detection, lifestyle intervention, and multidisciplinary care to address this global silent epidemic effectively.