Advancing bowel preparation: DWJ1609 represents a patient-centered evolution in colonoscopy preparation

doi:10.3748/wjg.118991

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 14, 2026; 32(30): 118991
Published online Aug 14, 2026. doi: 10.3748/wjg.118991

Advancing bowel preparation: DWJ1609 represents a patient-centered evolution in colonoscopy preparation

Iyad A Issa, Taly Issa

Iyad A Issa, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Abu Dhabi 41475, United Arab Emirates

Taly Issa, Medical School, University of Nicosia, Nicosia 24005, Cyprus

Author contributions: Issa IA designed the overall concept and outline of the manuscript; Issa T contributed to the discussion and design of the manuscript; both authors contributed to the writing, and editing the manuscript, illustrations, review of literature and they have read and approved the final manuscript.

AI contribution statement: Claude AI was used for English language polishing of the manuscript.

Conflict-of-interest statement: Both authors declare no conflict of interest.

Corresponding author: Iyad A Issa, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Marina Village, Villa No. A21, Abu Dhabi 41475, United Arab Emirates. iyadissa71@gmail.com

Received: January 16, 2026
Revised: February 24, 2026
Accepted: April 21, 2026
Published online: August 14, 2026
Processing time: 188 Days and 16.6 Hours

Core Tip

Core Tip: DWJ1609 is a next generation bowel preparation tablet that reduces sulfate content by 75% while maintaining excellent cleansing efficacy. In a phase III randomized trial, it significantly improved tolerability—particularly nausea and headache—without compromising safety. This patient-centered formulation may enhance adherence to colorectal cancer screening and represents a meaningful evolution in bowel preparation strategies.

Issa IA, Issa T. Advancing bowel preparation: DWJ1609 represents a patient-centered evolution in colonoscopy preparation. World J Gastroenterol 2026; 32(30): 118991 [DOI: 10.3748/wjg.118991]

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