Liu H, Jiang WY, Mao FF. Letter to the Editor: Advancing the clinical translation of triptolide and quercetin in hepatocellular carcinoma: A commentary on dual JAK-STAT/mTOR inhibition. World J Gastroenterol 2026; 32(30): 117813 [DOI: 10.3748/wjg.117813]
Corresponding Author of This Article
Fei-Fei Mao, Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 227 Chongqing South Road, Shanghai 200086, China. maofeifei01@126.com
Research Domain of This Article
Oncology
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letter
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Liu H, Jiang WY, Mao FF. Letter to the Editor: Advancing the clinical translation of triptolide and quercetin in hepatocellular carcinoma: A commentary on dual JAK-STAT/mTOR inhibition. World J Gastroenterol 2026; 32(30): 117813 [DOI: 10.3748/wjg.117813]
World J Gastroenterol. Aug 14, 2026; 32(30): 117813 Published online Aug 14, 2026. doi: 10.3748/wjg.117813
Letter to the Editor: Advancing the clinical translation of triptolide and quercetin in hepatocellular carcinoma: A commentary on dual JAK-STAT/mTOR inhibition
Hua Liu, Wei-Yi Jiang, Fei-Fei Mao
Hua Liu, Fei-Fei Mao, Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200086, China
Wei-Yi Jiang, Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315000, Zhejiang Province, China
Co-first authors: Hua Liu and Wei-Yi Jiang.
Author contributions: Liu H and Jiang WY contributed equally as co-first authors; Liu H wrote the original draft; Mao FF contributed to conceptualization, writing, reviewing and editing; Jiang WY participated in drafting the manuscript; all authors have read and approved the final version of the manuscript.
AI contribution statement: The use of AI-assisted tools (specifically Deepseek and ChatGPT for the initial translation, and Grammarly for language polishing) was employed to enhance the readability and language accuracy of the manuscript. However, these tools were not utilized for data analysis or for any writing assistance beyond the scope of polishing. The core writing and scientific argumentation are entirely the author's achievements.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Fei-Fei Mao, Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 227 Chongqing South Road, Shanghai 200086, China. maofeifei01@126.com
Received: December 18, 2025 Revised: January 21, 2026 Accepted: March 6, 2026 Published online: August 14, 2026 Processing time: 217 Days and 3.6 Hours
Core Tip
Core Tip: Tong et al provide a robust preclinical foundation for the combined triptolide and quercetin therapy for hepatocellular carcinoma. They demonstrate synergistic anti-tumor activity through a multi-pathway mechanism where both compounds bind to key proteins like Janus kinase 1, signal transducer and activator of transcription 3, phosphoinositide 3-kinases, and mammalian target of rapamycin, disrupting carcinogenic signaling. This research adds to the growing body of work on natural product-based cancer therapies. To advance this promising start, future investigations using immunocompetent models, detailed pharmacokinetic studies, and deeper mechanistic validation are essential. Such efforts may translate these findings into a viable clinical strategy, aligning with the broader push toward precision medicine in oncology.
